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研究論文


Regional brain activation during rectal distention and attenuation with alosetron in a nonhuman primate model of irritable bowel syndrome.
Fujii R, Awaga Y, Nozawa K, Matsushita M, Hama A, Natsume T, Takamatsu H
FASEB BioAdvances 2022; https://doi.org/10.1096/fba.2022-00048



Adenosine A1R/A3R (Adenosine A1 and A3 Receptor) Agonist AST-004 Reduces Brain Infarction in a Nonhuman Primate Model of Stroke.
Liston TE, Hama A, Boltze J, Poe RB, Natsume T, Hayashi I, Takamatsu H, Korinek WS, Lechleiter JD
Stroke 2022; 53(1):238-248. doi: 10.1161/STROKEAHA.121.036396.



Pharmacological modulation of brain activation to non-noxious stimulation in a cynomolgus macaque model of peripheral nerve injury.
Hama A, Yano M, Sotogawa W, Fujii R, Awaga Y, Natsume T, Hayashi I, Takamatsu H
Molecular Pain 2021; 17: 1-19.



A longitudinal comparison in cynomolgus macaques of the effect ofbrimonidine on optic nerve neuropathy using diffusion tensor imagingmagnetic resonance imaging and spectral domain opticalcoherence tomography.
Takahashi N, Matsunaga N, Natsume T, Kitazawa C, Itani Y, Hama A, Hayashi I, Shimazawa M, Hara H, Takamatsu H
Heliyon 2021. DOI: https://doi.org/10.1016/j.heliyon.2021.e06701



Pharmacologic Modulation of Noxious Stimulus-evoked Brain Activation in Cynomolgus Macaques Observed with Functional Neuroimaging.
Shirai T, Yano M, Natsume T, Awaga Y, Itani Y, Hama A, Matsuda A, Takahatsu H
Journal of the American Association for Laboratory Animal Science. 2019 Jan 1-10. DOI: https://doi.org/10.30802/AALAS-JAALAS-18-000143



Brain Activation in a Cynomolgus Macaque Model of Chymopapain-Induced Discogenic Low Back Pain: A Preliminary Study.
Ushirozako H, Yoshida Go, Togawa D, Omura T, Hasegawa T, Yamato Y, Banno T, Arima H, Oe S, Mihara Y, Yamada T, Natsume T, Ogawa S, Awaga Y, Takamatsu H, Matsuyama Y
Surg Relat Res 2019; 3(4): 368-376.



Distinguishing analgesic drugs from non-analgesic drugs based on brain activation in macaques with oxaliplatin-inducued neuropathic pain.
Shidahara Y., Natsume T., Awaga Y., Ogawa S., Yamoto K., Okamoto S., Hama A., Hayashi I., Takamatsu H., Magata Y.
Neuropharmacology. 2019 Feb 25.https://doi.org/10.1016/j.neuropharm.2019.02.031.



Pain-related behavior and brain activation in cynomolgus macaques with naturally occurring endometriosis.
Yano M., Matsuda A., Natsume T., Ogawa S., Awaga Y., Hayashi I., Hama A., Takamatsu H.
Human Reproduction. 2018 Dec 31. https://doi.org/10.1093/humrep/dey383.



Pain-Related Behavior and Brain Activation in a Cynomolgus Macaque Model of Postoperative Pain.
Hama A., Natsume T., Ogawa S., Awaga Y., Hayashi I., Matsuda A., Takamatsu H.
CNS & Neurological Disord Drug Targets. 2018 May 15. doi: 10.2174/1871527317666180515121350.



Gaps in Understanding Mechanism and Lack of Treatments: Potential Use of a Nonhuman Primate Model of Oxaliplatin-Induced Neuropathic Pain
Aldric Hama,Takahiro Natsume,Shin’ya Ogawa,Noriyuki Higo,Ikuo Hayashi,Hiroyuki Takamatsu
Pain Research and Management Volume 2018, Article ID 1630709, 11 pages



Brain activity changes in a macaque model of oxaliplatin-induced neuropathic cold hypersensitivity.
Nagasaka, K., Yamanaka, K., Ogawa, S., Takamatsu, H., Higo, N.
Sci Rep. 2017 Jun 27;7(1):4305



Antinociceptive effect of clinical analgesics in a nonhuman primate model of knee osteoarthritis
Ogawa, S., Awaga, Y., Takashima, M., Hama, A., Matsuda, A., Takamatsu, H.
European Journal of Pharmacology. 2016; 786: 179-185



Knee osteoarthritis pain following medial meniscectomy in the nonhuman primate
Ogawa, S., Awaga, Y., Takashima, M. Hama, A., Matsuda, A., Takamatsu, H.
Osteoarthritis and Cartilage. 2016; 24(7): 1190-1199



Pharmacological comparison of a nonhuman primate and a rat model of oxaliplatin-induced neuropathic cold hypersensitivity
Shidahara, Y., Ogawa, S., Nakamura, M., Nemoto, S., Awaga, Y., Takashima, M., Hama, A., Matsuda, A., Takamatsu, H.
Pharmacology Research & Perspectives. 2016; 4(1): e00216



Chemotherapy-Induced Peripheral Neuropathic Pain and Rodent Models.
Hama, A., Takamatsu, H.
CNS & neurological disorders drug targets. 2016; 15(1): 7-19.



Beyond Rodent Models of Pain: Non-Human Primate Models for Evaluating Novel Analgesic Therapeutics and Elaborating Pain Mechanisms.
Hama, A., Toide, K., Takamatsu, H.
CNS & Neurological Disorders - Drug Targets (Formerly Current Drug Targets - CNS & Neurological Disorders) 12(8)=E.ecember 2013.



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